A Dispersion Operator for Geometric Semantic Genetic Programming

Recent advances in geometric semantic genetic programming (GSGP) have shown that the results obtained by these methods can outperform those obtained by classical genetic programming algorithms, in particular in the context of symbolic regression. However, there are still many open issues on how to improve their search mechanism. One of these issues is how to get around the fact that the GSGP crossover operator cannot generate solutions that are placed outside the convex hull formed by the individuals of the current population. Although the mutation operator alleviates this problem, we cannot guarantee it will find promising regions of the search space within feasible computational time. In this direction, this paper proposes a new geometric dispersion operator that uses multiplicative factors to move individuals to less dense areas of the search space around the target solution before applying semantic genetic operators. Experiments in sixteen datasets show that the results obtained by the proposed operator are statistically significantly better than those produced by GSGP and that the operator does indeed spread the solutions around the target solution

Actin/alpha-actinin-dependent transport of AMPA receptors in dendritic spines: role of the PDZ-LIM protein RIL

The efficacy of excitatory transmission in the brain depends to a large extent on synaptic AMPA receptors, hence the importance of understanding the delivery and recycling of the receptors at the synaptic sites. Here we report a novel regulation of the AMPA receptor transport by a PDZ (postsynaptic density-95/Drosophila disc large tumor suppressor zona occludens 1) and LIM (Lin11/rat Isl-1/Mec3) domain-containing protein, RIL (reversion-induced LIM protein). We show that RIL binds to the AMPA glutamate receptor subunit GluR-A C-terminal peptide via its LIM domain and to alpha-actinin via its PDZ domain. RIL is enriched in the postsynaptic density fraction isolated from rat forebrain, strongly localizes to dendritic spines in cultured neurons, and coprecipitates, together with alpha-actinin, in a protein complex isolated by immunoprecipitation of AMPA receptors from forebrain synaptosomes. Functionally, in heterologous cells, RIL links AMPA receptors to the alpha-actinin/actin cytoskeleton, an effect that appears to apply selectively to the endosomal surface-internalized population of the receptors. In cultured neurons, an overexpression of recombinant RIL increases the accumulation of AMPA receptors in dendritic spines, both at the total level, as assessed by immunodetection of endogenous GluR-A-containing receptors, and at the synaptic surface, as assessed by recording of miniature EPSCs. Our results thus indicate that RIL directs the transport of GluR-A-containing AMPA receptors to and/or within dendritic spines, in an alpha-actinin/actin-dependent manner, and that such trafficking function promotes the synaptic accumulation of the receptors

A gravitationally lensed quasar discovered in OGLE

Indexación: Scopus; Web of Science.We report the discovery of a new gravitationally lensed quasar (double) from the Optical Gravitational Lensing Experiment (OGLE) identified inside the ~670deg2 area encompassing the Magellanic Clouds. The source was selected as one of ~60 'red W1-W2' mid-infrared objects from WISE and having a significant amount of variability in OGLE for both two (or more) nearby sources. This is the first detection of a gravitational lens, where the discovery is made 'the other way around', meaning we first measured the time delay between the two lensed quasar images of -132 < tAB < -76 d (90 per cent CL), with the median tAB ~-102 d (in the observer frame), and where the fainter image B lags image A. The system consists of the two quasar images separated by 1.5 arcsec on the sky, with I ~20.0mag and I ~19.6mag, respectively, and a lensing galaxy that becomes detectable as I ~21.5 mag source, 1.0 arcsec from image A, after subtracting the two lensed images. Both quasar images show clear AGN broad emission lines at z=2.16 in the New Technology Telescope spectra. The spectral energy distribution (SED) fitting with the fixed source redshift provided the estimate of the lensing galaxy redshift of z ~0.9 ± 0.2 (90 per cent CL), while its type is more likely to be elliptical (the SED-inferred and lens-model stellar mass is more likely present in ellipticals) than spiral (preferred redshift by the lens model). © 2018 The Author(s). Published by Oxford University Press on behalf of the Royal Astronomical Society.https://academic.oup.com/mnras/article/476/1/663/483368

Inspection of Computed Tomography (CT) Data and Finite Element (FE) Simulation of Additive Manufactured (AM) Components

This is the author accepted manuscript. The final version is available from the publisherOne of the challenges of working with Additive Manufactured (AM) metal parts involves checking accuracy and reliability before production. Techniques used Computed Tomography (CT) scans, 3D image processing, and Finite Element (FE) simulation help detect problems prior to costly faults. A workflow has been developed by Synopsys, ANSYS, North Star Imaging, and the University of Pittsburgh to streamline this often-complex process, with applications to analyzing metal AM-produced lightweight brackets and a component from Moog, Inc. Software like Synopsys Simpleware™ is used to generate robust models from 3D scans of AM parts to compare original CAD models with ‘as-built’ geometries, and to export a FE mesh for simulation in ANSYS. This method enables identification of design deviations early in the design process, and how their impact might be tackled prior to production. For the Moog application, unexpected defects were identified for aerospace parts to inform future design iteration

Effect of structural defects on anomalous ultrasound propagation in solids during second-order phase transitions

The effect of structural defects on the critical ultrasound attenuation and ultrasound velocity dispersion in Ising-like three-dimensional systems is studied. A field-theoretical description of the dynamic effects of acoustic-wave propagation in solids during phase transitions is performed with allowance for both fluctuation and relaxation attenuation mechanisms. The temperature and frequency dependences of the scaling functions of the attenuation coefficient and the ultrasound velocity dispersion are calculated in a two-loop approximation for pure and structurally disordered systems, and their asymptotic behavior in hydrodynamic and critical regions is separated. As compared to a pure system, the presence of structural defects in it is shown to cause a stronger increase in the sound attenuation coefficient and the sound velocity dispersion even in the hydrodynamic region as the critical temperature is reached. As compared to pure analogs, structurally disordered systems should exhibit stronger temperature and frequency dependences of the acoustic characteristics in the critical region.Comment: 7 RevTeX pages, 4 figure

Altering the properties of graphene on Cu(111) by intercalation of potassium bromide

The catalytic growth on transition metal surfaces provides a clean and controllable route to obtain defect-free, monocrystalline graphene. However, graphene's optical and electronic properties are diminished by the interaction with the metal substrate. One way to overcome this obstacle is the intercalation of atoms and molecules decoupling the graphene and restoring its electronic structure. We applied noncontact atomic force microscopy to study the structural and electric properties of graphene on clean Cu(111) and after the adsorption of KBr or NaCl. By means of Kelvin probe force microscopy, a change in graphene's work function has been observed after the deposition of KBr, indicating a changed graphene-substrate interaction. Further measurements of single-electron charging events as well as X-ray photoelectron spectroscopy confirmed an electronic decoupling of the graphene islands by KBr intercalation. The results have been compared with density functional theory calculations, supporting our experimental findings

OGLE16aaa - a Signature of a Hungry Super Massive Black Hole

We present the discovery and first three months of follow-up observations of a currently on-going unusual transient detected by the OGLE-IV survey, located in the centre of a galaxy at redshift z=0.1655. The long rise to absolute magnitude of -20.5 mag, slow decline, very broad He and H spectral features make OGLE16aaa similar to other optical/UV Tidal Disruption Events (TDEs). Weak narrow emission lines in the spectrum and archival photometric observations suggest the host galaxy is a weak-line Active Galactic Nucleus (AGN), which has been accreting at higher rate in the past. OGLE16aaa, along with SDSS J0748, seems to form a sub-class of TDEs by weakly or recently active super-massive black holes (SMBHs). This class might bridge the TDEs by quiescent SMBHs and flares observed as "changing-look QSOs", if we interpret the latter as TDEs. If this picture is true, the previously applied requirement for identifying a flare as a TDE that it had to come from an inactive nucleus, could be leading to observational bias in TDE selection, thus affecting TDE-rate estimations.Comment: Accepted in MNRAS Letter

Critical sound attenuation in a diluted Ising system

The field-theoretic description of dynamical critical effects of the influence of disorder on acoustic anomalies near the temperature of the second-order phase transition is considered for three-dimensional Ising-like systems. Calculations of the sound attenuation in pure and dilute Ising-like systems near the critical point are presented. The dynamical scaling function for the critical attenuation coefficient is calculated. The influence of quenched disorder on the asymptotic behaviour of the critical ultrasonic anomalies is discussed.Comment: 12 RevTeX pages, 4 figure